Models for, human melioidosis, tuberculosis, anthrax, as well as infections with SARS-associated. outbreaks in humans [27]. All figure content in this area was uploaded by Sascha Knauf, Respiratory Animal Models in the Common Marmoset (Callithrix jacchus).pdf, All content in this area was uploaded by Sascha Knauf on Jun 19, 2016, Respiratory Animal Models in the Common Marmoset (Callithrix ja, Respiratory Animal Models in the Common Marmoset, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of. ; Schlumbohm, C.; Switalla, S.; Neuhaus, V.; Forster, C.; Fieguth, H.G. In this paper, we give a concise

Macrophage and polymorphonuclear, and developed human-like melioidosis including high mortality [40,41]. in epithelia of the nasal olfactory mucosa and the upper, [66]. Monkey. It was possible to depict leptospiral antigens in the affected areas of lung, parenchyma with immunofluorescence techniques [55].

Lung injury was expressed by initial edema, followed by an acute interstitial inflammation [22]. Deep sequencing detected relatively few genetic changes in H1N1pdm viruses replicating in any infected animal. Further Models with Respiratory Implications, For the reason that research on toxins needs reliable anim. Thus, the pathogenesis of experimental inoculation of TMAdV in common marmosets resembled the mild, self-limiting respiratory infection typically seen in immunocompetent human hosts rather than the rapidly progressive, fatal pneumonia observed in 19 of 23 titi monkeys during the prior 2009 outbreak. Community outbreak of adenovirus, Taiwan, 2011. Furthermore, splenocytes were retrieved 7 days post onset of treatment, restimulated with CHDMAPP or heat-killed B. pseudomallei and the cultured γ9(+) T cells demonstrated no reduction in IFN-γ response when CHDMAPP+IL-2 animals were compared to IL-2 only treated animals. Common marmosets (Callithrix jacchus) are frequently used as translational animal models for human diseases.

© 2008-2020 ResearchGate GmbH. Infection caused dehydration, weight loss and hepatic, injury [55]. Since 1991, a completely new choleragenic Vibrio cholerae, designated 0139 has emerged in southern India and spread to other parts of India and to neighbouring countries, setting in motion the 8th cholera pandemic.

Beside its, unacceptable use as a mass destruction agent, there is a high risk of occupational exposure to low, levels of sarin, e.g., for personnel that has to destroy stockpiles or any kind of medical staff which, comes into contact with intoxicated victims [58,59]. Twins infected with the same, of disease whereas twin animals exposed to different strains showed disparities specific for the, group [50]. Due to hematopoietic chimerism, marmosets but not OWMs, give birth to, immunologically identical twins, which facilitates matched control study designs [4]. Furthermore, the marmoset’s nasal cavity closely resembles the, human nasal cavity’s morphology, a requirement for translational inhalation studies with a high. Results:

Common marmosets (Callithrix jacchus) are small non-human primates (NHPs) that are often used for respiratory research. Similar to humans and in contrast to, the monopodial branching pattern in rodents, the marmoset’s bronchial tree shows dichotomous, branching [10,11]. The analysis revealed a high incidence of predominantly mild and multifocal interstitial pneumonia (32.99 %) of unknown etiology in most cases. Of all applied cytological stains, three allowed differentiation of eosinophils and neutrophils and, thus, reliable quantification in blood smears: May-Grünwald-Giemsa stain, Congo Red and Naphthol AS-D Chloroacetate-Esterase. There's also a link for members of the public to gain access to health information through NHS Direct. We found that the previous studies predicted the in vivo responsiveness of γ9(+) T cells to the CHDMAPP+IL-2 treatment and significant expansion of the numbers of peripheral and splenic γ9(+) T cells were observed. Studies of influenza transmission are necessary to predict the pandemic potential of emerging influenza viruses. Animal models with a high predictive value for human trials are needed to develop novel human-specific therapeutics against respiratory diseases. We inoculated four marmosets with the 2009 pandemic virus A/California/07/2009 (H1N1pdm) and housed each together with a naïve cage mate. Currently, both ferrets and guinea pigs are used in such studies, but these species are distantly related to humans. Unlike in macaques or humans inf.

The first NHP, animal model for studies of respiratory melioidosis was established in common marmosets by Nelson, and colleagues [40]. 5. Monkey on a tree in India in a national Park waterfalls Athirapilly, Kerala. Here we evaluate the efficacy of the phosphoantigen CHDMAPP, in combination with IL-2, as a therapy against B. pseudomallei infection, in vivo. The CHDMAPP treatment regime had no effect on the progression of respiratory melioidosis and this was despite the presence of elevated numbers of γ9(+) T cells in the spleen, liver and lung and an increased proportion of IFN-γ(+) cells in response to infection.